October may be Menopause Awareness Month, but around here every month is menopause awareness month. In this episode of the Stay Juicy Podcast, I dive into a topic that has the entire midlife world buzzing: GLP-1s, GIPs, and the powerful role of estrogen in metabolism.
If you’ve been doing everything “right” and still watching your body change in ways that don’t make sense, this is your episode. It’s not about discipline — it’s about biology.
Why Your Metabolism Feels Different
When estrogen is steady, your metabolism hums. She keeps blood sugar balanced, helps your muscles burn fuel efficiently, and directs fat to friendlier places — hips and thighs — instead of your belly. But as estrogen declines, insulin sensitivity changes, inflammation increases, and that stubborn abdominal fat shows up.
This isn’t your fault. It’s chemistry. And understanding that opens the door to smarter, kinder solutions.
Enter the GLP-1s and GIPs
GLP-1s (like Ozempic®, Wegovy®, and Mounjaro®) and the next-gen dual agonists (like Zepbound® and retatrutide) work by mimicking hormones your gut already makes — hormones that regulate hunger, blood sugar, and fullness.
When used appropriately, these medications can help women in midlife not just lose weight but improve metabolic health.
Recent research from the Mayo Clinic and the Endocrine Society suggests that women on both GLP-1 therapy and estrogen replacement see greater weight-loss results and better long-term stability than those using GLP-1s alone.
Beyond the Quick Fix
The secret isn’t just in the shot — it’s in the synergy.
GLP-1s can quiet appetite and balance insulin, but estrogen remains your metabolic MVP. Together, they can restore that rhythm your body once had naturally.
However, real success still comes from a foundation of movement, resistance training, sleep, stress management, and nutritional care. Weight-loss medications are tools, not replacements for self-connection.
The Future of Midlife Medicine
The next generation of therapies — from oral GLP-1s like Rebelsus® to triple-action peptides — are part of a revolution in how we view menopause. It’s not a downhill slide; it’s an upgrade waiting to happen.
At its core, this is about empowering women to understand their biology and to choose what supports them best — whether that’s lifestyle, hormone therapy, medication, or all three.
Listen & Learn More
🎧 Listen to the full episode of the Stay Juicy Podcast on Spotify or Apple Podcasts.
📺 Watch on YouTube.
🌐 Explore more at DrArianna.com.
Your metabolism isn’t broken — it’s evolving. Learn how to work with it, not against it.